Safety rules for the NCLEX
These are the 48 safety rules from the PrepScore bank, in full. Each card is the reasoning shortcut behind a class of questions — the thing a wrong answer usually means you were missing — and each names the clinical pack it comes from.
All 48 cards
Post-stroke = NPO until dysphagia screened. The 3-oz water bedside test is gatekeeper. Family preference does not override safety screen.
Comfort Care ProNeutropenic precautions = reverse isolation: protect the patient FROM the environment. Different mindset from contact/droplet/airborne which protect others FROM the patient.
Infection Control MasteryDiffuse, concave (upward-sloping) ST elevation with PR depression points to pericarditis, not STEMI. Pleuritic, positional pain (worse lying flat, better leaning forward) reinforces it. Avoid anticoagulation in pericarditis with effusion — it raises the risk of hemorrhagic tamponade.
Cardiac & PerfusionA pacemaker spike without a following QRS is not a heartbeat. In a paced patient with new symptoms, calculate the TRUE ventricular rate by counting QRS complexes. Failure to capture is an emergency: bed rest, fall precautions, transcutaneous pacing setup, device interrogation — atropine has limited use because the problem is mechanical, not vagal.
Cardiac & PerfusionVerbal warnings don't reduce fall risk. Prevention bundle: remove/secure throw rugs, install grab bars, brighten lighting, review high-risk meds (benzos on Beers list), verify walker/cane fit, ensure accessible phone or wearable alert. Engage family in home setup. PT/OT consult for home assessment.
Basic Care & Health Promotion75-80% of dietary sodium is in processed and restaurant food. Effective HF / HTN diet teaching addresses deli, soups, frozen meals, take-out, and condiments — not just the table salt shaker. Teach label-reading (<140 mg = low). Involve the cook + shopper. Daily weight + 2/3 rule (call if gain ≥ 2 lb/day or 3 lb/week). Caution salt substitutes (KCl) if patient is on K-sparing meds.
Basic Care & Health PromotionSuction MOUTH BEFORE NOSE (nose stimulation triggers gasp → aspiration). Apgar 7-10 = good, 4-6 = needs support, 0-3 = resuscitation. Skin-to-skin promotes thermoregulation + bonding + breastfeeding. Prophylaxis: vitamin K 1 mg IM, erythromycin eye ointment, hepatitis B vaccine. Delay first bath ≥ 6-24 hours.
Basic Care & Health PromotionPatients with visual / cognitive / language barriers + social isolation need adaptive teaching: home health, return demonstration, large-print materials, family engagement, phone-camera workarounds, and follow-up scheduling. Off-loading is the single biggest determinant of diabetic foot ulcer healing. A printed handout is documentation, not teaching.
Basic Care & Health PromotionVancomycin trough: 30-60 min BEFORE next dose. Blood cultures: 2 sets, different peripheral sites, BEFORE antibiotics. 24-h urine: discard first void + collect all + final void at 24 h + keep on ice. AFB sputum x3 early morning + airborne precautions if TB suspected. Always label specimens AT BEDSIDE with 2 identifiers.
Diagnostics & Lab InterpretationUTI in elderly often presents as confusion, falls, decreased appetite, change in baseline function — NOT classic dysuria/frequency. Always consider UTI for any acute change. Treat symptomatic UTI; do NOT treat asymptomatic bacteriuria in elderly (IDSA guidelines — causes resistance + side effects without benefit). Mental status returns to baseline after treatment.
Geriatric Specialty CareUGIB = hematemesis + melena (source above Treitz; NSAIDs, varices, ulcer). LGIB = hematochezia (source below Treitz; diverticular, AVM, cancer). Both: 2 large-bore IVs + isotonic + type & cross + monitor + reverse anticoag if active bleed. UGIB → EGD + PPI; LGIB → colonoscopy. Resuscitate before scope.
GI DisordersAsterixis + confusion + elevated ammonia in cirrhosis. Treatment: lactulose titrated to 2-3 soft BMs per day (not fixed dose) + rifaximin secondary. IDENTIFY TRIGGER: GI bleed, infection (SBP, UTI, pneumonia), constipation, electrolytes (K + Mg), sedatives, TIPS. Maintain protein 1.0-1.5 g/kg — don't severely restrict (outdated). Diarrhea is goal, not side effect (titrate, don't stop).
GI DisordersDuodenal ulcer = pain 2-3 h after meals + at night (empty stomach, relieved by food). Gastric ulcer = pain with meals. Causes: H. pylori + NSAIDs. Treatment: triple therapy (PPI + clarithromycin + amoxicillin x 10-14 days) or quadruple. STOP NSAIDs. Watch complications: bleeding, perforation, obstruction, malignancy (gastric).
GI DisordersPeriumbilical → RLQ pain + McBurney's tenderness + Rovsing's sign + low fever + leukocytosis. Treatment: NPO + IV fluids + IV antibiotic + IV analgesia + ICE (not heat — heat ruptures) + NO laxatives (rupture risk) + lap appendectomy within 24 h. Watch for perforation (sudden pain relief, then diffuse rigid abdomen + fever).
GI DisordersVesicants (DOX, vincristine): STOP + ASPIRATE WITH IV in place + antidote (dexrazoxane DOX; hyaluronidase vinca). Drug-specific compress (cold for DOX, warm for vinca). Neutropenic precautions when ANC < 500. Body fluids hazardous 48 hr.
High-Alert MedicationsNorepi/epi/dopa/vasopressin extravasation = ischemic necrosis. STOP + aspirate + PHENTOLAMINE 5-10 mg SC around site + WARM compress. CENTRAL line preferred for sustained infusion. MAP ≥ 65 in septic shock.
High-Alert MedicationsSurgical timeout = correct patient (2 identifiers) + correct site (marked + visible) + correct procedure + position + allergies + antibiotic timing + equipment + imaging + fire risk. Time pressure NEVER overrides verification. Any identifier mismatch = stop until resolved. Any team member, including the nurse, has the authority + the duty to stop.
Infection Control & Procedural SafetyCytotoxic spills require chemo spill kit, double-glove + gown + N95 + goggles + shoe covers. Isolate area + move bystanders. Skin contact = wash with soap + water for at least 15 minutes; eye contact = 15-min saline irrigation. Bag contaminated materials in cytotoxic waste container. Incident report + occupational health follow-up — never general housekeeping for cytotoxic.
Infection Control & Procedural SafetyMRSA, VRE, CRE all require contact precautions (gown + gloves all entry). Use dedicated equipment (stethoscope, BP cuff, thermometer) that stays in the room. Alcohol rub effective for MRSA/VRE/CRE; reserve soap-and-water for C. diff + visibly soiled. Do NOT cohort different MDROs (e.g., MRSA + VRE) in the same room — they can acquire each other. Same organism can be cohorted with infection control approval.
Infection Control & Procedural SafetySurgical site infection prevention: pre-op chlorhexidine bath, hair removal with clippers (not razors — razors cause microabrasions), glucose target 80-180 (especially DM), antibiotic within 60 minutes of incision (verify redosing), maintain normothermia (≥ 36°C). Each element is independently linked to SSI risk.
Infection Control & Procedural SafetyDON: gown → mask → eye protection → gloves. DOFF: gloves → eye protection → gown → mask (mask removed OUTSIDE the room). Hand hygiene between every step. Touch only the inside / clean parts during removal. Never pull a gown over your head (drags contamination across face). Never reuse single-use masks between patients.
Infection Control & Procedural SafetyComprehensive geriatric assessment includes cognition (Mini-Cog or MoCA), falls (TUG > 12 sec = high risk), depression (PHQ-9), polypharmacy (Beers list review with pharmacy), ADL + IADL, driving safety, vision + hearing, home safety, social support. Refer PT for balance + falls, SW for social + bereavement, pharmacy for med review.
Lifespan & WellnessUse symptom-triggered CIWA-based benzodiazepines (lorazepam) to control withdrawal. Always give thiamine 100 mg BEFORE any dextrose to prevent Wernicke's. Watch the trajectory: rising CIWA + autonomic + early visual hallucinations = pre-DT, treat now. Seizure precautions + sitter + low-stim; restraints are last resort.
Mental Health & Substance UseFlashbacks are involuntary re-experiencing triggered by sensory stimuli. Step back; identify yourself by name + role; use the patient's name; low voice; orient to present time + place + situation. NEVER touch without permission during a flashback. Ask before flashback what triggers + what helps — apply to care plan + handoff. Restraint re-traumatizes.
Mental Health Therapeutic CommunicationTimeline: 6-12 hr minor → 12-24 hr hallucinations → 24-48 hr seizure → 48-96 hr DELIRIUM TREMENS (mortality 15%). CIWA-Ar guides benzodiazepine (lorazepam/chlordiazepoxide) symptom-triggered. THIAMINE 100 mg IV/PO BEFORE GLUCOSE (prevent Wernicke encephalopathy = ophthalmoplegia + ataxia + confusion → Korsakoff). Replace Mg/K/Phos. Seizure precautions. Long-term: naltrexone/acamprosate/disulfiram + AA + counseling.
Mental Health Disorders Deep DivePPH = EBL > 500 vag or > 1000 C-section. 4 T's: TONE (atony #1) — fundal massage + EMPTY BLADDER + oxytocin → methergine (AVOID in HTN) → carboprost (AVOID in asthma) → misoprostol → TXA → balloon (Bakri) → surgery. TRAUMA (laceration/hematoma). TISSUE (retained — D&C, look for accreta). THROMBIN (DIC — FFP/cryo/platelets). Massive transfusion if continued bleed.
Maternal & Newborn Deep DiveNeonatal sepsis signs: temperature INSTABILITY (often hypothermia not fever), respiratory distress, poor feeding, lethargy, hypoglycemia, jaundice, hypotonia. Early-onset (< 72 hr): GBS, E. coli, Listeria. Workup + empirical AMPICILLIN + GENTAMICIN within 1 hr; don't wait for cultures. RDS in preterm: surfactant deficiency → CPAP first, then SURFACTANT via ETT + mechanical ventilation. Antenatal steroids prevent. Distinguish from TTN (term, post C-section, resolves 24-72 hr), meconium aspiration, pneumothorax, CHD.
Maternal & Newborn Deep DiveFemur/pelvis fracture 24-72 hr post → respiratory (hypoxia, dyspnea) + neuro (confusion, restlessness) + petechial rash (upper body, axilla, conjunctiva). Treatment is SUPPORTIVE: supplemental O2, mechanical ventilation if needed, fluids, hemodynamic support. NO specific antidote. Anticoagulation does NOT treat FES (vs PE — clot vs fat). Differentiate from PE.
Musculoskeletal & TraumaAlendronate/risedronate: take in MORNING on EMPTY stomach + FULL glass of water + remain UPRIGHT (sit/stand) ≥ 30 min + no food / other meds / calcium for ≥ 30 min after. Adverse: esophagitis, jaw osteonecrosis (notify dentist before invasive work), atypical femur fractures, hypocalcemia. Add calcium 1000-1200 mg + vit D 800-1000 IU + weight-bearing exercise + fall prevention.
Musculoskeletal & TraumatPA eligibility uses LKW — the last time the patient was confirmed neurologically normal — NOT when symptoms were found. Hypoglycemia is the major mimic; check glucose. Imaging (non-contrast CT) is first to differentiate ischemic from hemorrhagic. Aggressively dropping BP in ischemic stroke can worsen ischemia; allow permissive HTN up to 220/120 unless tPA is planned (then < 185/110).
Neurological EmergenciesSudden 'worst headache of life' that peaks in seconds = SAH until proven otherwise. CT first (most sensitive within 6 h). If CT negative with high suspicion, LP for xanthochromia. SAH BP target SBP < 140–160 to reduce rebleed (UNLIKE ischemic stroke). Start nimodipine 60 mg q4h for 21 days to prevent vasospasm. Secure aneurysm (clip or coil) early.
Neurological EmergenciesPostpartum hemorrhage is EBL > 500 (vaginal) or 1000 (C-section) or any sign of hemodynamic compromise. First-line: fundal massage + bladder decompression + increase oxytocin. Second-line uterotonics by patient: methylergonovine NOT in HTN; carboprost NOT in asthma; misoprostol generally OK. Escalate to Bakri/surgery for refractory.
Maternal & NewbornHELLP often mimics flu or indigestion. Look for Hemolysis (LDH, schistocytes, indirect bilirubin) + Elevated Liver enzymes + Low Platelets. Treat as severe-features preeclampsia + plan for delivery. Avoid empiric platelet transfusion without active bleeding/surgery indication.
Maternal & NewbornAbruption = painful, dark bleeding, rigid tender uterus, often hidden volume loss. Previa = painless bright red bleeding. NEVER perform a digital vaginal exam in 3rd-trimester bleeding until placenta location confirmed by ultrasound — exam over previa can cause catastrophic hemorrhage.
Maternal & NewbornCroup = viral, gradual URI prodrome, barking cough, inspiratory stridor, low-grade fever, child alert. Epiglottitis = bacterial (H. flu), sudden high fever, drooling, tripod position, toxic appearance, often unvaccinated. Treatment: croup = cool mist + nebulized racemic epinephrine + dexamethasone; epiglottitis = NO throat exam, keep upright with parent, immediate OR with anesthesia + ENT.
Pediatric Emergencies & Common ConditionsRSV bronchiolitis is viral. AAP guidelines: supportive care (O2 if hypoxic, nasal suction, hydration, isolation). Bronchodilators + steroids NOT routinely recommended. Antibiotics only for secondary bacterial infection. Admission criteria: SpO2 < 90%, severe distress, poor feeding/dehydration, apnea, < 3 mo, high-risk comorbidities.
Pediatric Emergencies & Common ConditionsDown (trisomy 21): hypotonia + flat face + upslanting + single palmar + protruding tongue. Screen: heart (AVSD common), hearing, vision, thyroid, leukemia, atlantoaxial (avoid contact sports if instability), sleep apnea, GI atresia. CP: non-progressive motor disorder; multidisciplinary (PT/OT/SLP/ortho/neuro/nutrition); botox/baclofen for spasticity; feeding/nutrition support. Autism: M-CHAT-R 18+24 mo; early intervention (ABA/SLP/OT) improves outcomes; visual schedules + sensory-friendly + predictable + avoid restraints + parent partnership.
Pediatric Specialty Deep DiveRed flags: injuries inconsistent with mechanism or developmental stage (e.g., spiral femur in non-ambulatory), multiple injuries various healing stages, delay seeking care, story changes, unusual locations (torso/ears/neck/buttocks), patterned injuries (belt, hand, burn), retinal hemorrhage + subdural in infant (shaken baby/abusive head trauma). Nurses are MANDATED REPORTERS — report on REASONABLE SUSPICION (not proof). Skeletal survey + CT + retinal exam. Objective documentation (photos, body diagrams, exact quotes). Screen caregiver for IPV.
Pediatric Specialty Deep DiveUpper airway obstruction in PACU differential: tongue (most common — jaw thrust + airway adjunct), laryngospasm (stridor — BVM positive pressure + jaw thrust ± succinylcholine + reintubation), aspiration (lateral + suction + O2), edema. NC alone can't overcome obstruction. Negative-pressure pulmonary edema can develop after relieved obstruction → O2 + diuretic + supportive vent.
Perioperative & PACUProfessional boundaries: decline gifts beyond token (often defined by agency policy), decline off-the-clock visits / dual relationships, decline witnessing patient wills or financial documents (appearance of undue influence). Underlying needs (loneliness, anxiety, isolation) get referred to social work, chaplain, community resources — not nurse extracurricular coverage.
Professional Practice & LeadershipBladder scan to confirm. For volumes > 800-1000 mL, drain 500-1000 mL initially then clamp + pause 15-30 min before continuing (rapid drainage = mucosal hemorrhage + vasovagal hypotension). Prefer straight cath for one-time; Foley if recurrent. Monitor for post-obstructive diuresis (UO > 200 mL/hr) — replace fluids + monitor electrolytes.
Renal & UrinaryWBC casts = upper tract (pyelonephritis). Fever + flank pain + CVA tenderness. Sepsis criteria + lactate ≥ 2 + hypotension = urosepsis. Sepsis bundle within 1 hr: cultures BEFORE antibiotics, broad-spectrum IV abx within 1 hr, 30 mL/kg crystalloid for hypotension/lactate ≥ 4, reassess. Source control: change/remove Foley if source. Admit for IV antibiotics + fluids.
Renal & UrinaryAn ABG read in isolation can mislead. Low pH + high CO2 in a sleepy, hard-to-arouse client is CO2 narcosis — even if SpO2 is acceptable. Do not increase oxygen; that can suppress the remaining respiratory drive. Anticipate non-invasive ventilation.
Respiratory & OxygenationDysphagic / stroke patients often aspirate WITHOUT coughing. Suspect aspiration when gastric residuals climb + tachypnea + new crackles + fever appear, even with no obvious cough. HOLD the feed, elevate HOB to ≥45°, verify NG placement, notify provider. Long-term: post-pyloric tube, smaller boluses, swallow re-evaluation.
Reduction of Risk PotentialActive or suspected pulmonary TB requires a negative-pressure room (door closed) with empiric isolation on clinical suspicion. Healthcare workers wear a fit-tested N95 (or PAPR). When the patient must leave the room, the PATIENT wears a surgical mask. Do not confuse contact and airborne; do not use a surgical mask as HCW PPE for TB.
Safety & Essential CareRestraints are last-resort, applied only after less restrictive measures fail, with a specific provider order (type, indication, duration, max time), monitored q15 min for behavior, released q2 h per policy for ROM/skin/toileting. Tie to the bed FRAME with a quick-release knot — never to a side rail. Re-evaluate need every shift. Chemical restraint (sedation for behavior) follows the same rules.
Safety & Essential CareUse 2 identifiers (name + DOB, or name + MR#) at every encounter — every med, every procedure, every specimen, every blood product. Have the patient ACTIVELY state name + DOB when possible (not yes/no to 'are you Mr. Brown?'). Room number and face recognition are NOT identifiers. Same-name patients deserve extra discipline + chart flagging.
Safety Standards & IdentificationRestraint requires SPECIFIC provider order (type + reason + duration + max time) — NO PRN restraint orders. Behavior assessment q15 min while restrained. Release q2h for ROM + skin + toileting + hydration + mental status. Re-evaluation each shift + at order expiration. Discontinue at earliest indication of safety — least-restrictive principle. Documentation must be real-time, not backfilled.
Safety Standards & IdentificationPractise the whole pack, tagged and explained
Every item carries its Client Needs category and clinical judgment step, so a wrong answer names the step that failed.
Frequently asked questions
How many safety rules are there?
48 in the PrepScore bank, all shown on this page with the clinical pack each comes from.
Are these official NCSBN rules?
No — they are PrepScore's teaching distillations, written to compress the reasoning that NCLEX-style questions reward. The test plan defines what is tested; these are how to think about it.
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